I use Skype extensively for communication with clients as well as low cost international calls. But, I have to admit that every time the configuration of the sound system on my Asus V6J (Gentoo powered) it takes me several days to get the microphone working again (even though it continues to work with every other application!)

So, as much for my benefit as for yours, here are the kmix settings for the Intel HDA sound card which appears to work with Skype.

Kmix Output settings

Kmix switches

Kmix Input settings